Understand weight-loss peptides. Then source them with confidence.
Mechanism-level profiles and agonist-class comparisons for GLP-1, dual, and triple agonist research compounds, plus current pricing from Core Power Peptides, the USA-made, third-party-tested supplier we vet and recommend.
Tirzepatide is the compound most researchers start with
Tirzepatide is the dual-agonist reference compound in this class, the one most newer multi-receptor agonists are measured against. The supplier we recommend is Core Power Peptides, and this is the vial we point researchers to first.
- ≥99% purity, HPLC + MS/MS verified per batch
- Dual GIP/GLP-1 receptor agonism, the reference compound for this research class
- Third-party ISO-certified lab testing, COA available per lot
- Ships from FDA-registered, cGMP-compliant US labs in 2–5 days
Disclosure: links marked “Shop” or “Check price” go to Core Power Peptides, our research-peptide supplier partner. We may earn a commission when you purchase through these links, at no added cost to you. This never changes which compounds we cover or how we describe them.
50 mg vial · $6.40/mg · lyophilized powder
Struck-through price is the supplier’s own pre-sale listing. Checked Sep 29, 2026.
- Category
- GIP / GLP-1 Dual Agonist
- Sequence length
- 39 amino acids
- Research status
- Approved analog exists
- Best for
- The dual-agonist most researchers reach for first
How sourcing works
Research the compound
Review the mechanism, agonist class, and current research status for the peptide you are interested in.
Compare pathway and price
Weigh receptor pathway against current pricing across the GLP-1, dual, and triple agonist compounds we track.
Source from a vetted supplier
Buy directly from Core Power Peptides: USA-made, third-party tested, with a COA available for every batch.
Weight-loss peptide compounds
14 compounds studied across GLP-1, dual, and triple agonist pathways, plus growth-hormone and NNMT-adjacent research chemicals. Compounds currently in stock link straight to pricing.
Tesofensine
Triple Monoamine Reuptake Inhibitor
A small-molecule triple monoamine reuptake inhibitor studied for appetite suppression through a central nervous system pathway entirely separate from incretin receptor agonism, often researched alongside GLP-1 compounds as a mechanistically distinct comparator.
GLP-1 compound pricing, compared
Current Core Power Peptides pricing for every incretin-pathway compound we track, so you can weigh mechanism against cost before choosing one to research.
| Compound | Pathway | Best for | Vial | Price | $/mg | |
|---|---|---|---|---|---|---|
TirzepatideEditor's pick | GIP / GLP-1 Dual Agonist | The dual-agonist most researchers reach for first | 50 mg | $320$416 | $6.40/mg | Shop |
Semaglutide | GLP-1 Receptor Agonist | Single-pathway GLP-1 research; the reference comparator for newer agonists | 10 mg | $75 | $7.50/mg | Shop |
Cagrilintide | Long-Acting Amylin Analog | Amylin-pathway research, commonly paired with semaglutide | 10 mg | $220$286 | $22.00/mg | Shop |
Mazdutide | GLP-1 / Glucagon Dual Agonist | Glucagon-pathway research as an alternative to GIP-based dual agonists | 10 mg | $80$104 | $8.00/mg | Shop |
Retatrutide | GIP / GLP-1 / Glucagon Triple Agonist | Three-receptor (GIP, GLP-1, glucagon) mechanism research | — | Not stocked | — | Unavailable |
Tesofensine | Triple Monoamine Reuptake Inhibitor | Non-incretin appetite-pathway research | 80 mg | $109 | $1.36/mg | Shop |
Liraglutide | GLP-1 Receptor Agonist | A baseline GLP-1 comparator for newer incretin compounds | — | Not stocked | — | Unavailable |
Orforglipron | Oral Non-Peptide GLP-1 Agonist | Oral, non-peptide GLP-1 pharmacology comparisons | — | Not stocked | — | Unavailable |
Survodutide | GLP-1 / Glucagon Dual Agonist | Comparing GLP-1/glucagon dual agonism with three-receptor compounds | — | Not stocked | — | Unavailable |
Prices checked Sep 29, 2026. $/mg is the listed price divided by vial size, so compounds are comparable per milligram. Struck-through figures are the supplier’s own pre-sale listings.
Disclosure: links marked “Shop” or “Check price” go to Core Power Peptides, our research-peptide supplier partner. We may earn a commission when you purchase through these links, at no added cost to you. This never changes which compounds we cover or how we describe them.
One receptor, two, or three: how the agonist classes differ
Each additional receptor pathway changes what researchers are studying, not just how strong the effect is.
Triple agonist
Adds glucagon-receptor activation on top of GIP and GLP-1 signaling. The most mechanistically aggressive compound in this class, currently in late-stage trials.
3 of 3 receptor pathways
GLP-1 only
Single-pathway incretin agonism. The reference point this entire research field is compared against.
GIP / GLP-1 dual
Combines two incretin pathways in one molecule, associated with larger mean reductions than GLP-1 alone.
What proper sourcing looks like, and why we point researchers to Core Power Peptides
These are the checks we use to evaluate any supplier before recommending it. Core Power Peptides is the one we currently vouch for: FDA-registered, cGMP-compliant US labs, ≥99% purity on every batch, and independent ISO-certified lab verification.
Certificate of analysis
Every batch should ship with a COA verifying purity and identity through HPLC or mass spectrometry, not a generic template.
Independent third-party testing
In-house testing alone is not enough. Look for sourcing that is verified by a lab outside the manufacturer.
Cold-chain handling
Lyophilized peptides tolerate brief room-temperature shipping, but need refrigerated or frozen storage for long-term stability.
Reconstitution basics
Bacteriostatic water, sterile technique, and gentle swirling rather than shaking, which can denature the peptide.
Batch traceability
Lot numbers printed on the vial should trace back to a specific, dated certificate of analysis.
Latest research
All articlesFrequently asked questions
Research peptides sold for laboratory use sit in a regulatory gray area in most jurisdictions. Some compounds discussed here, including semaglutide and tirzepatide, also exist as FDA-approved prescription drugs sold only through pharmacies. Nothing on this site is intended for human use, self-administration, or as medical advice.
It means the compound is sold for laboratory research, not for consumption. It has not been evaluated by the FDA for safety or effectiveness in humans through this sourcing channel, even if an approved analog exists elsewhere.
Each added receptor pathway (GIP, then glucagon) changes the biology being studied, not just the strength of the effect. See the mechanism comparison above for a breakdown by compound.
Lyophilized (freeze-dried) peptides are generally more stable than peptides in solution, which is why they ship as powder. Suppliers typically recommend cold, dark, dry storage; always follow the storage terms printed on the certificate of analysis or product label. This site does not give preparation or handling protocols.
No. This site is an independent research and comparison resource. We link out to Core Power Peptides, a supplier we vet against the sourcing standards above, and we may earn a commission on purchases made through those links at no extra cost to you. See our affiliate disclosure below.
Import regulations for research chemicals vary widely by country and change often. Check your local laws before placing an order from any source.
A peptide is a short chain of amino acids, like semaglutide or retatrutide, and generally cannot survive digestion, which is why peptide-class compounds are typically injectable. A small-molecule agonist, like orforglipron or 5-Amino-1MQ, reaches the same or a related receptor through a chemically different, non-peptide structure that can often be taken orally.
Approval status reflects how far a specific formulation has moved through regulatory review for human prescription use, not how much research exists on the underlying receptor pathway. A compound can be well studied in research settings while still sitting in preclinical or clinical-trial status, and an approved analog existing elsewhere does not change the research-only sourcing channel discussed on this site.
It confirms that a lab independent of the manufacturer, not the seller grading its own product, ran purity and identity testing (typically HPLC for purity and mass spectrometry for molecular identity) on that specific batch. In-house-only testing is not equivalent, since it carries no independent check on the result.
The compound name is just a label for a specific molecule; the receptor pathway is what determines the biology being studied. Two compounds with very different names can share a mechanism, and two compounds that sound similar can target entirely different receptors, which is why this site organizes profiles by mechanism class (GLP-1, dual agonist, triple agonist, and so on) rather than alphabetically.
Disclosure: links marked “Shop” or “Check price” go to Core Power Peptides, our research-peptide supplier partner. We may earn a commission when you purchase through these links, at no added cost to you. This never changes which compounds we cover or how we describe them.
Ready to source your next compound?
Every compound on this site can be checked against current Core Power Peptides pricing and stock. Third-party tested, USA-made, and shipped in 2–5 days.
Shop Core Power PeptidesDisclosure: links marked “Shop” or “Check price” go to Core Power Peptides, our research-peptide supplier partner. We may earn a commission when you purchase through these links, at no added cost to you. This never changes which compounds we cover or how we describe them.